Restrained in her daily life, Ann feels she has lost her place in the world. Although she is respectful and polite towards her peers and elders, Ann is a bit more withdrawn and isolated from the rest of the kids at school due to becoming the subject of rumors regarding her and Kamoshida. Megami Tensei Wikia
Once the Aragami had reawakened, they began to take steps to ensure their continuted survival. With that in mind, Orochi sought out a family that had been attempting to sacrifice the Kushinada and put the Aragami to sleep again. Orochi killed the parents...but for their baby son, Orochi had a special plan. Implanting within him seven mitama, seven Aragami souls, Orochi charged little Mamoru Kusanagi with the task of watching over the Kushinada and ensuring that no harm would come to her...until they were ready. So even as he grew, Mamoru kept a watchful eye over little Kaede Kunikida, watching her grow and develop. He didn't know it then, but watching Kaede grow like this would stir up emotions later on he would have trouble controlling. For Kusanagi was not happy with his destiny. He sought freedom, and to do that, he thought, he would have to kill the Kushinada and let the pulse lock his masters in sleep. Mutated as he is by the seven mitama on his body, green blood flows in Kusanagi's veins, and he has the ability to transform his body somewhat. He can make blades sprout from his arms, and he has incredible physical ability, including his penchant for long and high jumps. However, without an eighth mitama, he lacks the strength or the abilities to take on Murakumo. But Kusanagi is not one to give up easily, and his unusual connection to Momiji (she and he both received their mitama from Orochi) will play a crucial role in the late stages of the conflict. As his name implies, "Mamoru" means protector, while "Kusanagi" comes from "Kusanagi-no-tsurugi", the Grass-Cutting Sword, a blade supposedly given by the Japanese gods to the emperor. -taken from Absolute Anime
Sakuya is the only human living in the Scarlet Devil Mansion, yet she is also the head maid. The official fanbook suggests she had been a vampire hunter before she began working in the mansion, but she was defeated by Remilia Scarlet who pitied her and gave Sakuya her current name. Though she looks about sixteen like the other girls, Sakuya has the ability to slow, stop and possibly reverse time. She seems to have been serving Remilia for a long time and may be far older then she looks. Socially, she interacts mainly with the others in the Scarlet Devil Mansion. Her talents are cooking, knife throwing and time manipulation. The latter two abilities characterize her appearances in-game, and led to frequent parodies in reference to Dio Brando of JoJo's Bizarre Adventure, who also controls time and throws knives. This reference goes so far as Sakuya using some of his poses in a game. She is often associated with dogs by other characters because she is serving as a demon's "faithful guard dog" even though she is a full blood human. Due to the inconsistent artwork depicting her bust between games, d�jinshi often make fun of her by indicating that she pads her breasts. (Source: Wikipedia)