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Director of National Epidemic Research Center. She's obsessed about Ebola virus. She seems to be carefree, cheerful person,but she takes her job as a doctor very seriously.

Age: 15 A tech whiz on Joe's team.

Born Jan 12, 2144 Planet Pizanne, The Cygnus Zone - Alfin was the Princess of the Planet Pizanne who left her home and royal status to join the Crushers. After the Pizanne incident she sneaks aboard the Minerva and takes the late Gambino's place as navigator. Perky, bubbly and easily intoxicated, Alfin is also quick-witted and fearless. She and Joe are romantically involved.

Born November 8, 2142 Planet Aramis, The Canis Major Zone - Joe is the headstrong leader of his Crusher Team, Joe became a Crusher at the age of ten and replaced his father as the active head of the Crushers. Now nineteen, he maintains his Triple A rating. Joe has an intensive dislike for authority (other than his own) and refuses to take orders from anyone, including his father. However, he does have a lighter side, which enables him to take the balance of a situation and to act quickly and calmly. He and Alfin are romantically involved.(From Wikipedia)

Tsukushi Makino is the main female character, and is one of the very few students at the prestigious Eitoku University to come from an "unwealthy" family. Her family is so poor that they can barely afford to pay Makino's tuition, but her parents push her on to continue school because they have a dream that she can "snag a rich man" and take them out of poverty. At the beginning of the manga, Makino was a poor, pig-tailed girl who had almost no friends at school and kept to herself. When one of her only friends falls down a staircase and bumps in the leader of the F4, Makino stands up for her friend (Domyoji was about to hurt her for bumping into him) and suffers the consequences. The next day, a red tag is hanging in her locker, which predicts future torment from the F4 and followers. But, unlike most of the F4's targets, Makino stands up for herself, showing how strong a "weed" can be. In this process, she changes to let her stubborn, hardworking ways show through, and in the end she turns all of the F4 into her friends. At first, Makino hates all of the F4 except Hanazawa Rui, (which she has romantic feelings towards). But, as Rui goes off to chase after Shizuka, Makino gets to know them, and even slowly falls in love with the hotheaded leader, Domyoji.

Domyouji Tsukasa is the leader of the F4. At the beginning of the series, he is Makino's biggest enemy, but as the story progresses, he becomes her love interest. Tsukasa is the heir to Domyoji Enterprises, and his family is extremely rich. They own various houses around the world, including an actual island, a house in Canada, and a house in New York City where his parents stay. Domyouji grew up somewhat lonely, as his parents were always overseas, and his sister—as loving as she could be—was either busy studying or, later in life, married and moved to Los Angeles. Also, his mother, Kaede, is cold to him, and although she loves him, wants to control his life. Tsukasa sometimes calls her "the old hag" and "witch". Before he met Makino, he was violent and ill-tempered, but after he became loyal and nice. As Tsukasa first started off being hard and tough to get though to; the author of Hana Yori Dango showed us thoughout the anime and manga that anyone who starts off being hard can also find their soft side because of love and that is shown though Tsukasa Domyouji.